Vidigal lab manuscripts:

Perez AR, Sala L, Perez RK, Vidigal JA. “Correction of Off-Targeting in CRISPR Screens Uncovers Genetic Dependencies in Melanoma Cells.” bioRxiv, 809970 2019. Link to full text

Sala L, Chandrasekhar S, Vidigal JA. “AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.” Frontiers in bioscience (Landmark edition) 25, 1-42 2020 review Download PDF.

Pre-2018 publications:

Perez AR*, Pritykin Y*, Vidigal JA*#, Chhangawala S, Leslie CS#, Ventura A#. “GuideScan software for improved single and paired CRISPR guide RNA design”. Nature Biotech doi:10.1038/nbt.3804 2017 *co-first and #co-corresponding author. Link to full text

Vidigal JA and Ventura A. “Rapid and efficient one-step generation of paired gRNA CRISPR/Cas9 libraries” Nat. Commun. 6:8083 doi: 10.1038/ncomms90832015. Link to full text

Han YC*, Vidigal JA*, Mu P*, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. “An allelic series of miR-17~02 mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.” Nat Genet. 2015 Jul;47(7):766-75. *co-first author. Link to full text

La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB. “In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.” Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72. Link to full text

Vidigal JA, Ventura A. “The biological functions of miRNAs: lessons from in vivo studies.” Trends Cell Biol. 2014 Dec 4 pii: S0962-8924(14)00197-4. Review. Link to full text

Maddalo D, Manchado E, Concepcion CP, Bonetti C, Vidigal JA, Han YC, Ogrodowski P, Crippa A, Rekhtman N, de Stanchina E, Lowe SW, Ventura A. “In vivo engineering of oncogenic chromosomal rearrangements with CRISPR/Cas9 system.” Nature. 2014 Dec 18;516(7531):423-7. Link to full text

Pennimpede T, Proske J, König A, Vidigal JA, Morkel M, Bramsen JB, Herrmann BG, Wittler L. “In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.” Dev Biol. 2012 Dec;372(1):55-67. Link to full text

Vidigal JA, Ventura A. “Embryonic stem cell miRNAs and their roles in development and disease.” Semin Cancer Biol. 2012 Oct;22(5-6):428-36. Review. Link to full text

Concepcion CP, Han YC, Mu P, Bonetti C, Yao E, D’Andrea A, Vidigal JA, Maughan WP, Ogrodowski P, Ventura A. “Intact p53-dependent responses in miR-34-deficient mice”. PLoS Genet. 2012;8(7). Link to full text

de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, Van Haeringen A, Geneviève D, Goldenberg A, Oufadem M, Manouvrier S, Munnich A, Vidigal JA, Vekemans M, Lyonnet S, Henrion-Caude A, Ventura A, Amiel J. “Germline deletion of the miR-17~92 cluster causes skeletal and growth defects in humans.” Nat. Genet. 2011 Sep 4; 43(10):1026-30. Link to full text

Vidigal JA, Morkel M, Wittler L, Brouwer-Lehmitz A, Grote P, Makura K, Herrmann BG. “An inducible RNA interference for functional dissection of mouse embryogenesis.” Nucleic Acids Res. 2010, 1–7. Link to full text